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Nimesulide (219), Vismodegib (220), New Pyrimidine-5-Carbonitriles (221), Sulfonamide-Pyrazole derivatives (222) and lariciresinol (223) exert regulatory effects on arachidonic acid metabolism by inhibiting COX-2, the specific drugs used are shown in Table 5

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If the phenotypes of the mutants can be successfully restored to wild type, this will confirm that only the correct genes have been deleted and further validate the specific phenotypes ascribed to each GDH mutant

PMC 3257725