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Subsequently, the full texts were reviewed separately by two different reviewers (R.K, Z.H, R.S and S.S)
Comparative Mechanisms with Other Agents Compared with metformin, which improves insulin sensitivity primarily through hepatic and muscular pathways, GLP-1 RAs act centrally and peripherally to influence appetite, glucose metabolism, and systemic inflammation
The difference comes from tirzepatides dual GIP/GLP-1 mechanism versus semaglutides single GLP-1 action
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