The system is no longer closed
NaCl helps the osmotic component, but a buffered version of NAD+ addresses the actual cause. Tesamorelin is the one people get backwards: its FDA label specifies sterile water, but that is regulatory convenience, not the better diluent
The sections below explain exactly why concentration matters, how to reconstitute properly, and how to draw accurate doses at every level from 2.5mg through 10mg
Tarpada SP, Morris MT, Lian J, Rashidi S
Other weight loss medications, such as Orlistat, Phentermine, and Contrave, work differently
And some are simply taking regulatory risk