Although pernicious anemia, or Addison-Biermer disease, had been recognized clinically in the mid-19th century, the associated neurologic, gastrointestinal, and hematologic manifestations were not recognized clinically and linked with pernicious anemia until the end of the 19th century (139)
However, their primary areas of celebrated efficacy differ, which is a key consideration when designing a study
Homocysteine accumulates in the blood when there is inadequate folate and/or vitamin B 12 for effective functioning of the methionine synthase enzyme (see Function)
This means the vitamin will get absorbed by the muscle and blood vessels directly
If youre still curious (or suspect you may really need them), get the shots in a doctors office, rather than a non-medical setting.
Allergic reactions to excipients (mannitol, bacteriostatic water preservatives) can mimic overdose symptoms and may require epinephrine