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in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )

5 That third pathway is why retatrutide is called a triple agonist rather than a dual agonist like Mounjaro, and why its trial weight-loss numbers are higher than those of single- or dual-action medications

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Seufert, J

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