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DSS-induced colitis in mice elicited pronounced symptoms, including reduced locomotor activity, decreased consumption of food and water, dull and lifeless fur, signs of depression-like behavior, huddling behavior, perianal swelling and congestion, diarrhea, bloody stools, and substantial weight loss
Synergistic with GLP-1 agonists - the CagriSema combination (cagrilintide + semaglutide) shows 15.6% weight loss
Review the evidence, understand the mechanism, and explore peptide alternatives that avoid this pro-angiogenic signal