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Due to the complex interaction of different factors that contribute to an effective immune response, there may be more than one correlate of protection, and the mechanisms of protection during natural infection may differ from those seen after vaccination
doi: 10.1007/978-981-99-1718-1_17 36 MacvaninMTGluvicZZafirovicSGaoXEssackMIsenovicER
This depends on the individual pain tolerance, needle size, injection technique, and injection site
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