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Semaglutide's most frequently reported adverse effects are gastrointestinal in nature, occurring in a dose-dependent manner

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Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

Novel dosage forms such as sublingual lozenges and buccal mucosal films can prolong local mucosal retention and facilitate rapid transepithelial absorption, laying a theoretical foundation for non-invasive semaglutide administration.Nevertheless, oral mucosal delivery still faces multiple inherent limitations and practical challenges