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While preclinical and early clinical studies have suggested that autophagy inhibition may enhance the therapeutic efficacy of MEK1/2 or ERK1/2 inhibition, 24,44 real-life data have thus far not supported the reliable impact of trametinib + hydroxychloroquine for the treatment of metastatic PDAC

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Preclinical toxicological data: Acute and subacute toxicity studies in rats did not reveal any mortality or significant organ toxicity, even at doses well above therapeutic doses (up to 100 times the effective dose)