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With semaglutide GLP-1, the first hormone-based weight loss medication of its kind, a new generation of safe, effective weight loss medications is now available

For this reason, the effectiveness cannot yet be conclusively assessed

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Here is the honest state of the data: Obesity (Phase 2, randomized controlled trial): the landmark New England Journal of Medicine Phase 2 trial in obesity established both the once-weekly dosing and the escalation approach, and reported the largest average weight reductions seen for a once-weekly agent with the caveat that the reduction had not fully plateaued at 48 weeks

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Discard the first day's readings and average the rest