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Secondary, safety and negative control endpoints For individual components of the primary endpoint, semaglutide versus sitagliptin reduced myocardial infarction (HR 0.81, 95% CI 0.70 to 0.92) and stroke (HR 0.84, 95% CI 0.71 to 0.99) in the expanded populations at low, moderate and high cardiovascular risk

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GLP-1 (glucagon-like peptide1) is a hormone made in the gut (and to some extent in the brain) that helps with: stimulating insulin secretion when glucose is high

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Morning administration on an empty stomach is preferred because AOD-9604 promotes fat mobilization, and morning dosing allows fat to be utilized as fuel during daytime activity