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Exclusion criteria included other forms of diabetes mellitus, pregnancy or lactation, contraindications to GLP-1RAs, previous or ongoing treatment with pioglitazone and/or Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and/or GLP-1RAs, inadequate ability to comply with follow-up or provide informed consent, implantable electronic devices (cardioverter defibrillators or pacemakers) contraindicating body composition assessment by segmental multifrequency bioelectrical impedance analysis (SMF-BIA- Seca mBCA 525), as indicated by the manufacturer (Seca GmbH & Co., KG, Hamburg, Germany), the use of oral contraceptives or corticosteroids, infection by viral hepatitis B and C, and excessive ethanol consumption (more than 30 grams/day in men and 20 grams/day in women)

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The overlap it does flag is symptomatic: nausea and diarrhea from semaglutide can stack on top of metformin's own gastrointestinal effects, particularly early in treatment

Inositol is a carbohydrate-related co-factor and choline is a phospholipid precursor, so the blend spans three different compound classes

Available at: (Accessed: 19 September 2024)

This antibody loading is shown in Figure 1 (step 1), in which the MSIA tips are applied using a simple iterative pipetting action (aspirating/dispensing)