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Upon ligand recognition, cytokine signaling, or a combination of both, MAIT cells instantaneously manufacture Th1/Th17 cytokines, including IFN-, TNF-, and IL-17, in an innate-like response

Kanayama, T., Kobayashi, N., Mamiya, S., Nakanishi, T

For the underlying logic of complementary-mechanism combinations, see Peptide Stacking Guide: The Science Behind Combination Research Protocols

intermittent dosing protocols exist specifically to mitigate this