essence trial semaglutide PDF) 2.4 mg in Participants With Metabolic Dysfunction‐Associated Steatohepatitis: Baseline Characteristics and Design of the Phase 3 Diabetes Dialogue: Semaglutide for MASH

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In the present study, we have not only unveiled the interaction of endosomal GLP-1R with the ER, but also its localisation to VAPB-containing ERMCSs, from where the receptor assembles a newly described PKA signalling nanodomain, enabling cAMP-dependent PKA activation at the interface between the ER and mitochondria

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