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Treatment with proton pump inhibitors (PPIs) or H2 blockers can address the acid component, often reducing burping as a secondary benefit

End-stage diabetes is increasingly becoming one of the main causes of chronic renal failure, timely intervention of DN to prevent its development into end-stage renal disease has become a priority

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In the wider literature, established evidence from randomised controlled trials, albeit in non-CKD populations, generally support GLP-1 RAs (notably once-daily semaglutide over 52 weeks) for HbA1c and weight benefits, owing to the strength of evidence demonstrating their role in body weight, glycaemic and blood pressure reduction [25, 27]

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For example, in infants fed a formula containing 40% fat as MCT, an average of no more than 47% of the administered 8:0 was oxidized (63)