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doi: 10.1016/j.molmet.2019.09.010 4 SalcedoITweedieDLiYGreigNH

Using these enzyme preparations with a defined GSH concentration (20 M) in the established two-step in vitro reactions, we found that the extent of conversion of the ultrafiltered flavan-3,3,4-triol ( 4 ) depended on the applied concentration of the purified Pt GSTF8, confirming that this enzyme is required and sufficient for the observed conversion to cyanidin (Extended Data Fig

A 2026 review in the New England Journal of Medicine noted that questions about long-term dosing and durability of results remain open areas of research, not settled strategy

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