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Wolf, and M.C Petrie, for the STEP-HFpEF Trial Committees and Investigators* Relevant literature The STEP-HFpEF group has previously published the study design and baseline patient characteristics of this RCT 2 Relevant RCTs below: Relevant Guidelines 2022 AHA/ACC/HFSA Guidelines of the Management of Heart Failure: A Report of the ACC/AHA Joint Committee on Clinical Practice Guidelines

Its physiology is real and its safety profile is reasonable, but the responsible provider frames it as antioxidant and detoxification support , not as a proven treatment for specific diseases or a guaranteed cosmetic result