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This is a mechanistic observation from preclinical work, not a recommendation for human use
Interactions of DPP-4 and integrin beta1 influences endothelial-to-mesenchymal transition
In addition, the dual InsR/IGF-IR inhibitor linsitinib can prevent the emergence of breast cancer cells that are resistant to long-term estrogen deprivation or antiestrogen treatment and inhibit growth of established ER+ breast cancer xenografts in ovariectomized mice [107]
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