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This should only be used if the patient has been confirmed to have had inadequate responses to other forms of treatment

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Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements

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An overdose of vitamin B12 through diet is hardly possible and also not known, since the required transport protein IF (intrinsic factor) and absorption via the intestinal mucosa are two major barriers

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[55] Vitamin B 12 serum levels are used to detect its deficiency, but do not distinguish its causes

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