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Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis
It doesnt seem to be going anywhere, and people are pouring money into it
Get the market news that matters in a five-minute read with Market Briefs, our free daily newsletter The limited availability of refrigerated transport and storage capacity has led to rising competition among shipping companies to secure these resources
In short, robust studies in rodents demonstrate that all GLP-1RAs may cross the BBB but at largely variable rates and speed, seemingly higher for older agents (eg, exenatide, lixisenatide) and lower for newer ones (eg, semaglutide, tirzepatide).100 101 Even the larger and/or more electrically charged compounds, such as semaglutide, could still reach the brain via circumventricular sites and active transporters.102 103 Other mechanisms, such as brain capillary binding or sequestration, have been understudied.99 Interactions between the endogenous GLP-1 system, both peripheral and central, and how these may be perturbed by exogenous GLP-1RAs are unclear.104 105 Translating these findings in humans is complex
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