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FGF21s effects on glycemic control and insulin sensitivity are likely mediated predominantly by FGFR1c signaling in adipose tissue, which should normally serve as one of the bodys main depots for excess calories in response to post-meal insulin
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When combined, these overlapping side effect profiles may worsen GI tolerability, particularly during the dose escalation phase when tirzepatide GI effects are already at their peak
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requires thiamine pyrophosphate [TPP]: Measurement of red blood cell transketolase activity is a convenient bioassay to test for TPP deficiency
The subjects response time or motor function may become slightly impaired or decreased after administration of higher doses
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