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And the people that are getting attention, whether its Andrew Huberman or yourself, a lot of people that are just doing evidence based stuff and being really rational about it and thats how theyre getting attention and other people are seeing them and going, I need to dunk on that guy in order to elevate my social profile

Weight loss with berberine differs by individual, Paulvin says, citing factors such as metabolism, hormone levels, and lifestyle and diet choices

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Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene, the direct target of every GLP-1 compound), MC4R (a melanocortin receptor central to satiety and energy balance), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) map the baseline metabolic terrain any compound acts on

Aim for products with 3-5g of fibre per serving, or consider adding fibre from whole foods such as fruit or oats if making your own shake

This article breaks down where the retatrutide trials stand, what the timeline to approval actually looks like, how it compares to drugs you can already access, and what your options are today if you don't want to wait two years