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Tirzepatide is dual-acting: it targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, offering a broader metabolic effect

Contact your GP or diabetes specialist nurse if: Body aches are severe, persistent, or progressively worsening despite self-care measures You develop muscle weakness that interferes with daily activities or mobility Aches are accompanied by dark-coloured urine, which could indicate rhabdomyolysis (a rare but serious condition involving muscle breakdown) [11] [12] You experience symptoms of dehydration that do not improve with increased fluid intake, such as dizziness, reduced urine output, or confusion Body aches are associated with signs of infection, including fever, chills, or localised redness and swelling Seek urgent medical attention (call 999 or attend A&E) if: You develop severe muscle pain with significant weakness, particularly if accompanied by dark urine You experience chest pain, severe abdominal pain, or difficulty breathing alongside body aches You have symptoms suggesting severe hypoglycaemia (confusion, loss of consciousness, seizures) You develop signs of pancreatitis, such as severe, persistent abdominal pain radiating to the back, with or without vomiting Call NHS 111 if you are unsure about the urgency of your symptoms or need advice outside of normal GP hours

Stay well-hydrated to prevent constipation Drinking plenty of water may help prevent constipation

Some patients experience mild digestive changes such as nausea or bloating, especially early in treatment