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In summary, PF and GLR have a pharmacological mixed effect ( 4.1.2 Anti-neuroinflammation and improvement of alzheimers disease NLRP1 and NLRP3 are core sensor proteins of the inflammasome, belonging to the NOD-like receptors (NLRs) family, and play a key role in innate immune defense, inflammatory diseases, and autoimmunity ( 4.1.3 Intestinal-brain axis protection It was found that treatment with SGD reduced the release of pro-inflammatory cytokines and enhanced the expression of tight junction proteins (occludin and claudin1), thus preventing lipopolysaccharide (LPS) from entering the bloodstream