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Journal of Dental Anesthesia and Pain Medicine, 2022, 1 1

evaluated GHK-Cu eye cream in 41 women with photodamage, finding 55% reduction in periorbital wrinkles

Clean the injection site with an alcohol swab and allow to dry completely Pinch a fold of skin and subcutaneous tissue between thumb and forefinger Insert a 29 or 30 gauge insulin needle at a 45 degree angle into the pinched tissue Inject the solution slowly and steadily Withdraw the needle and apply gentle pressure if needed Rotate injection sites daily to prevent localized irritation Site Rotation Alternating between medial and lateral sides of the Achilles area prevents accumulation of scar tissue from repeated injections at the same spot

Rapamycin addresses cellular senescence in the follicle microenvironment by inhibiting mTOR, while GHK-Cu works on Wnt signaling, inflammation, and androgen receptor sensitivity

It was originally studied in the context of gastrointestinal healing, where the parent protein appears to play a role in protecting the gut lining