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The IGFBPs have a central role in modulating the oncogenic actions of IGFs mediated by IGF1R signaling, but they also have well-documented functions that occur independently of IGF- and IGF1R-dependent pathways [17]

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Phospholipid-Gold Nanorods Induce Energy Crisis in MCF-7 Cells: Cytotoxicity Evaluation Using LC-MS-Based Metabolomics Approach

Blood 117 , 46674678 (2011)

The third body is in vivo rodent work, largely on muscle, bone, gut and neural tissue, some of it using the LR3 variant specifically because its altered clearance and reduced binding-protein capture change tissue exposure relative to native protein