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found that children with GDH-HI carrying the p.R221C mutations were prone to mild cognitive impairment, ADHD, and refractory epilepsy [23]

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By Molecular Dynamics simulation using the crystal structure of the complex, we first delineated the Lig4 clamp domain as a limited suitable target

This condition is called Sarcopenia (muscle poverty)

It also provides practical and case-driven opinions and recommendations on the optimal use of GLP-1RAs by discussing important patient factors and clinical considerations that will help to identify those who are most likely to benefit from this class of agents