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Summary: The SUSTAIN 6 trial investigated semaglutide's cardiovascular benefits in patients with T2DM

The science on this subject is quite clear

Get a baseline morning total testosterone, especially if you already have fatigue, low libido, or known low T

On the weight loss side, the 10mg dose of Mazdutide actually matches Tirzepatide 15mg in the same timeframe and the 16mg dose nearly matches Retatrutide, but as noted that appears to not be a viable dose

Verify current terms and operational experience directly before enrolling

Tirzepatide is a peptide medication that does not undergo hepatic metabolism through cytochrome P450 enzymes, minimizing the potential for many drug-drug interactions