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Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: A mechanism targeted by roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet

Papakonstantinou, I., Tsioufis, K., & Katsi, V

Cancer 19 (1), 145

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Most patients report feeling more energetic only after several weeks of consistent treatment , not immediately

While not every person benefits, and while nausea often resolves on its own after 2-3 weeks on a stable dose, any intervention that improves tolerability increases the likelihood that users remain on treatment long enough to achieve meaningful results