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44,102 Sensory testing methods include the 10 g monofilament test for pressure perception, 103 the 128 Hz tuning fork for vibration sense, 35 pinprick and temperature sensation tests for small fiber function, 104 and loss or reduction of ankle reflexes indicating large fiber involvement

Increased ROS production and stress can induce apoptosis, which may exacerbate the progression of Parkinson's disease [27]

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Therefore, it has been proposed that oxidative stress in the developing brains contributes to neuronal damage in genetically susceptible children, which is important in the pathophysiology of ASD