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L., Gao, D

A small uncontrolled open-label trial reported that receiving 120 mg pine bark extract, 60 mg vitamin C, and 30 IU vitamin E daily for 3 months in migraine patients led to a significant reduction in the headache frequency, severity, and migraine disability (91)

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Both probiotic bacteria significantly upregulated the expression of tight junction proteins compared to untreated mice and, thus, improved intestinal barrier function in the treated mice