So I wrote a little thing for @MolMetab sciencedirect.com/science/articl As we now appreciate, GLP-1 can target multiple brain regions and neuronal populations to reduce food intake, and the clinical results are increasingly impressive #obesity The ongoing SELECT trial will be pivotal for the field sciencedirect.com/science/articl From very modest weight loss with exenatide twice daily, the GLP-1 field has learned, by titration, dose escalation, higher Cmax, and better molecules, to achieve clinically meaningful #weightloss #T2D #obesity More progress to come #obesity described here sciencedirect.com/science/articl Beyond semaglutide and tirzepatide, where might we find the next GLP-1-based advances in #weightloss #obesity Take a look at the slope of the lines for the combination of cagrilintide + semaglutide and make projections out to 52 weeks thelancet.com/journals/lance Join the conversation

A word on injectable peptides A huge and largely unregulated market has emerged around injectable peptides, with most bought directly online - think longevity compounds, tanning agents, and recovery aids
When left uncontrolled, free radicals can do a lot of damage to our health
S., Ramachandran, V., van Lent, D
For those incorporating it into a weight loss program, injections are typically scheduled once per week to maintain energy and support metabolic function
So why, then, is social media all aflutter