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In a third trial, liraglutide significantly reduced weight by 8 pounds relative to placebo over 10 months in stable patients with bipolar disorder regardless of whether they were taking an antipsychotic (McElroy SL et al, J Clin Psychopharm 2024;44(2):8995)

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Hold the bottle horizontally and shake from left to right for 10 seconds, then hold it vertically and shake from top to bottom for 10 seconds

GLP-1R causes a reduction in hepatic steatosis and inflammation and increases fat metabolism mediated by increasing hepatic insulin sensitivity [52,53,54]