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3 GLP-1R localization and mechanistic pathways in metabolic and behavioral regulation GLP-1 Rs exhibit high expression in pancreatic -cells in both rodents and humans, where they play a pivotal role in mediating glucose-dependent insulin secretion (Nauck et al., 1993

2025;10:eadl3852

Beta-carotene is a precursor to vitamin A

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A subgroup analysis of EXSCEL outcomes in patients with T2D and established CVD at baseline showed a 10% reduction in the risk of MACE with exenatide QW versus placebo ( p = 0.047) [Citation50]

Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from approved agents such as semaglutide or tirzepatide