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Particularly for tirzepatide, in the mixed effects model on a subset of the data with therapy duration greater than 180 days, there is a positive coefficient with therapy duration and weight regain after cessation with a significant P value

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Some are better suited for muscle repair, while others reduce inflammation

The body's physiological response tries to restore body weight from prior malnourishment

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Genome-wide H3K27ac ChIP-seq analyses revealed enrichment of this active histone modification at genes encoding the oxLDL receptor, a marker of atherosclerosis, and other inflammation-related genes in monocytes following BCG vaccination, suggesting transcriptional activation of these pro-atherogenic genes (157)