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The key is the intent and the dose

Patients undergoing surgery should inform their surgical/anaesthetic team and consider discontinuing supplementation at least two weeks beforehand, following local hospital policy for non-essential supplements

Is mitochondrial dysfunction a cause of insulin resistance

SECTION 8 Exposure Controls / Personal Protection Exposure Limits: None established

Although the 100 mg of niacinamide in this injection is relatively modest compared to gram doses used to treat cholesterol, diabetic patients should still have their blood sugar observed, as even moderate niacinamide supplementation could necessitate small adjustments in diabetes medications

Nature 491 , 449453 (2012)