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If heart rate increases remain problematic despite these measures, your physician may consider additional evaluation (such as ECG, electrolyte testing, or thyroid function tests), dose reduction, temporary treatment interruption, or discontinuation if clinically indicated

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2 After 12 months, the treatment group had significantly greater reductions in RA disease activity, pain scores, and several markers of cardiovascular risk, including total cholesterol and HbA1c (a measure of average blood sugar levels)

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