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Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression

doi: 10.1016/s1474-4422(18)30295-3, 42 DuX

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Causes of Poor Sleep: Stress, an overactive mind, hormonal imbalances, and underlying inflammation

Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools

A deficiency can cause fatigue, low mood, and even brain fog