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Nature 653 , 770775 (2026)

View full bio Written by Melissa Chester, BHSA

Given the limited generalizability, the results should be interpreted as hypothesis-generating signals that require confirmation through traditional surveillance systems and prospective studies in representative populations, the authors wrote

The accurate answer is therefore that retatrutide is being used for weight-loss research within clinical trials, but it should not currently be used by members of the public as an independently sourced weight-loss treatment

However, some compounders may be using semaglutide sodium or semaglutide acetate, which are salt forms that may not work the same as the approved form

Participants in a 2021 study of injections lost an average of 14.9% of their body weight after 68 weeks