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International journal of physiology, pathophysiology and pharmacology, 2018, 10(3): 132

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Proteomic studies further confirmed that ApoE3 improves cerebrovascular function by inducing extracellular matrix-stabilizing proteins such as Timp3, whereas ApoE4 exacerbates pathological progression by suppressing lipoprotein metabolism-related proteins and activating the complement system [88, 91]

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