Individuals with a positive screening test result for hepatitis B surface antigen, hepatitis C virus antibody, or HIV types 1 or 2 antibodies were excluded
Despite similar overall weight loss between groups as measured by DEXA, the composition of weight loss differed substantially
Even within the food domain, several methodological issues make summarizing data across studies difficult: studies enrolled small sample sizes, used diverse pharmacological agents (e.g., exenatide, liraglutide, lixisenatide) with different dosing regimens, and mixed acute versus chronic designs
Research on GLP-1 therapy discontinuation suggests that certain metabolic improvements show partial persistence even after weight regain
4 DPP-4 inhibitors decrease serum DPP-4 enzyme activity responsible for degradation of GLP-1 by more than 80% and thereby restore GLP-1 to physiologic levels
If you have an existing medical condition or are taking any other medications that may lead to interactions, consult your medical provider with any questions