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Furthermore, there is a lack of randomized control trials assessing the benefits of topical glutathione alone

This mechanism is different from the previously suggested theory of increasing GSH levels

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CAFs-induced ECM remodeling results in increased tissue stiffness and the activation of mechanotransduction signaling pathways, such as integrin-FAK and YAP/TAZ signaling, thereby conferring increased malignancy to tumors (121)