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The in vivo effects of AT-7687 were evaluated in obese cynomolgus monkeys, and when combined with the GLP-1 analogue liraglutide, AT-7687 enhances weight reduction induced by liraglutide and improves glycemic control and lipid metabolism (51)

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The observed difference between the individuals with type 1 diabetes and UFMs (Table 1) was in contrast to the cross-sectional serum proteomics study of Zhang et al, in which the authors reported downregulation of GPX3 in type 1 diabetes and type 2 diabetes [4]

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