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Expert Opin Drug Discovery (2014) 9:122351

From the selected studies, the following data were extracted: first authors name, publication year, sample size, study location, mean age of participants, intervention (type, dose, and duration of supplementation), study design and end-point values (as means and sd) for the number of follicles, endometrial thickness, TT, progesterone, serum LH levels, serum FSH levels, E2 and SHBG in both intervention and control groups

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Market Size Estimation and Data Triangulation Bottom-Up Approach The bottom-up approach involved aggregating segment-level data, such as: Company revenues Product-level sales Installed base/usage volumes Adoption and penetration rates Pricing analysis This method was primarily used when detailed micro-level market data were available

2 vials cover ~100 doses with some margin

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