Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)
Accessed 9/17/2024, Wright CJ, Milosavljevic S, Pocivavsek A
doi:10.2147/PTT.S485061 He Y, Xu B, Zhang M, et al
This is critical for both shedding pounds and maintaining them
But as with any powerful medication, there can be some downside
There are no data to support improved compliance with anti-retroviral therapies in HIV-positive patients taking tesamorelin