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This muscle loss reduces metabolic rate, impairs function, and contributes to weight regain when medication stops

doi:10.1007/s00125-004-1342-6 Grant SF, Thorleifsson G, Reynisdottir I, et al

Papaccio, F., DArino, A., Caputo, S., & Bellei, B

Document the financial burden of untreated obesity on your overall healthcare costs

It is not known whether or not semaglutide will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma in humans

In the absence of robust data to support the safety around the use of GLP-1 agonists in pregnancy and inconsistent but possible association with hypertensive disorders of pregnancy, this medication should continue to be halted during pregnancy. Preconception Use of GLP-1s Rather than looking at the use of GLP-1s during pregnancy, the first of the studies looked at exposure prior to conception, though the study cohort included a proportion of patients who did not stop the medication until after conception