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Supplementary material The Supplementary Material for this article can be found online at: References 1 AbdelmasihR.SaeedZ.AshrafB.AbdelmaseihR.NasserH

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For comparison with leaching of molecular dye, similar PLGA nanoparticles were loaded with Nile red, a popular dye used for labeling PLGA and other polymers 50 , and found to leach 32.2 6.7% of initial load after only 6 hrs

The endogenous ligand was finally identified in 1999 by Kojima and colleagues: ghrelin, a 28-amino-acid peptide produced mainly by the stomach