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Description

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A Balanced Act of Mitochondrial Biogenesis and Mitophagy Mitochondrial function is multifaceted in response to cellular energy homeostasis and metabolism, including calcium homeostasis, amino acid metabolism, pyridine synthesis, cellular replication, apoptosis, reactive oxygen species (ROS) production, and senescence (Spinelli and Haigis, 2018)

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The involvement of stress response genes in regulating apoptosis in HOSC were confirmed through higher expression levels of stress response genes such as SOD3 (FC=4.66, qvalue =0.0141) and GPX3 (FC=6.81, qvalue =0.0006) suggesting the role of stress response genes in rescuing HOSC from undergoing apoptosis in spite of disruptive mitochondrial OXPHOS

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