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The metabolic adaptations that defend higher body weight return when medication support ends

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If a patient on semaglutide 2.4 mg (Wegovy) has not met that threshold after 16 weeks, switching to tirzepatide is a reasonable next step supported by that guideline framework

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It is true that normally when cutting back on calories and fat, our body stores fat and our metabolism slows down

Lee and Jun 2016)