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10.1016/j.jbiomech.2024.112386 129 RongM.LiuD.XuX.LiA.BaiY.YangG.et al (2024)

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That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed